Table 3

Frequency of SMN1 allele pairings

Allele pairings	Caucasian	Ashkenazi Jewish	Asian	African American	Hispanic
Non-carrier
2+2	0.0011	0.0065	0.0032	0.0748	0.0059
2+1	0.0621	0.1462	0.1058	0.3931	0.1416
1+1	0.9081	0.8230	0.8720	0.5169	0.8439
Total	0.9713	0.9756	0.9810	0.9848	0.9914
Carrier
2+1^D*	1.7E–05	3.6E–05	2.0E–05	7.7E–05	1.2E–05
2+0	0.0009	0.0019	0.0011	0.0041	0.0007
1+1^D	0.0005	0.0004	0.0003	0.0002	0.0001
1+0	0.0272	0.0220	0.0175	0.0108	0.0078
Total	0.0286	0.0243	0.0189	0.0152	0.0086
Affected
1^D+1^D*	7.1E–08	5.1E–08	2.0E–08	3.1E–08	6.2E–09
1^D+0*	7.6E–06	5.5E–06	2.1E–06	3.3E–06	6.7E–07
0+0	2.0E–04	1.5E–04	5.7E–05	8.8E–05	1.8E–05
Total	2.1E–04	1.5E–04	5.9E–05	9.1E–05	1.9E–05

*These genotype frequency estimates lack precision because of the limited data for the 1^D allele frequency.11