Summary of differences between painlessness caused by SCN9A, NTRK1 and PRDM12 mutations
| Congenital insensitivity to pain | Congenital insensitivity to pain with anhidrosis | ||
|---|---|---|---|
| Gene | SCN9A | PRDM12 | NTRK1 |
| Inheritance | Autosomal recessive | Autosomal recessive | Autosomal recessive |
| Pain | Impaired ability to feel pain | ||
| Autonomics | Sweat: normal Lacrimation: normal | Sweat: normal Lacrimation: reduced | Sweat: anhidrosis, recurrent febrile episodes, hypothermia in cold Lacrimation: may be reduced |
| Cranial nerves | Smell: anosmia | Smell: normal Corneal reflexes: may be absent Recurrent Staphylococcus aureus infections | Smell: normal Corneal reflexes: may be absent Recurrent S. aureus infections |
| Peripheral nerves | Inability to sense pain | Inability to sense pain | Inability to sense pain and temperature |
| CNS | Normal intellect, otherwise normal development | Mental retardation, variable | |
CNS, central nervous system.